Ultrasound Biophysics and Bioengineering Lab Google Scholar


Education

  • Ph.D. University College London, 2008
  • M.S. University of Patras, 2005
  • B.S. Technological Educational Institute of Athens, 2003

Teaching Interests

Professor Arvanitis’ teaching interests include courses in acoustics, medical ultrasound, biomechanics, and numerical methods at both the undergraduate and graduate levels. He emphasizes the integration of theoretical principles with practical applications. His teaching approach engages students through problem-solving and project-based learning, with the goal of developing critical thinking and a strong foundation in acoustics, mechanical engineering, and biomedical engineering.

Research Interests

Professor Arvanitis’ research investigates the fundamental mechanisms by which ultrasound-mediated thermal and mechanical stresses influence biological function and mass transport in tissues. His laboratory leverages acoustic cavitation and linear and nonlinear wave propagation to engineer spatially precise, feedback-controlled systems for non-contact modulation of complex biological processes. These efforts establish new paradigms for controlling biological function through physical forces and enable targeted cell and gene delivery approaches, as well as tools to monitor and modulate cell activity in healthy and diseased tissues, particularly in the brain.

Recent Publications

  • H. Lee, V. Menezes, S. Zeng, C. Kim, C. M. Baseman, J.-H. Kim, S.  Padmanabhan, P. Premdas, N. Djeddar, A. Bryksin, N. Pandey, P. Anastasiadis, A. J. Kim, T. J. MacDonald, C. Bettegowda, G. F. Woodworth, F. J. Herrmann, and C. Arvanitis “Data-driven feedback identifies focused ultrasound exposure regimens for improved nanotheranostic targeting of the brain” Advanced Science, e17834, 2026.
  • A. Alva, C. Kim, P. Premdas, Y. Ferry, H. Lee, N. Lal, J. Bowen, E. Botchwey, B. Lindsey, C. Arvanitis “Imaging of macrophage accumulation in solid tumors with ultrasound” Nature Communications, 16 (1), 6322, 2025.
  • Y. Guo, H. Lee, C. Kim, C. Park, A. Yamamichi, P. Chuntova, M. O. Bernabeu, H. Okada, H. Jo, & C. Arvanitis “Ultrasound frequency-controlled microbubble dynamics in brain vessels leads to differential gene expression in the blood-brain barrier and augments CAR-T cell trafficking in gliomas”, Nature Communications, 15 (1), 8021, 2024.
  • H. Lee, Y. Guo, J. L. Ross, S. Schoen Jr, L. Degertekin, and C. Arvanitis  “Spatially targeted brain cancer immunotherapy with closed loop controlled focused ultrasound and immune checkpoint blockade” Science Advances, eadd2288, 2022.
  • C. Arvanitis, G. B. Ferraro, and R. K. Jain “The blood–brain barrier and blood–tumor barrier in brain tumors and metastases” Nature Review Cancer 20, pp 26–41, 2020.