MP 6407 Radiation Biology and Oncology

MP 6407 Radiation Biology and Oncology
Spring

Credit Hours:	3-0-3
Prerequisites:	NRE 6756 Radiation Physics
Corequisite:
Course Description:	Radiation lesions and repair, mechanisms of cell death, cell cycle effect, radiation sensitizers and protectors, tumor radiobiology, relative sensitivities of human tissues, and radiation carcinogenesis.
Textbook:	Eric J. Hall, Radiobiology for the Radiologist, 5th Edition, Lippincott, Williams and Wilkins, 2000
Instructor:	Chris Wang (Fall 2004) and Joseph Ting

I. Radiation Injury and repair
(a) Radiation chemistry of water
(b) Structure of DNA and chromatin and chromosome
(c) Radiation-induced lesions
(d) Excision repair
(e) Repair of DNA/chromosome damage

II. Survival Curve Theory
(a) Target theory
(b) Survival curve models

III. Mechanisms of Cell Death
(a) Apoptosis
(b) Reproductive cell death

IV. Cell Cycle Effect
(a) Cell kinetics and cycle phases
(b) Radiosensitivity on cell cycle phases

V. Modifiers of Radiation Response
(a) Oxygen effect and other radiosensitizers
(b) Radioprotectors

VI. Relative radiation sensitivities of human tissues

VII. Tumor kinetics and Radiobiology
(a) The growth fraction and cell loss from tumors
(b) Basic tumor structure and physiology
(c) Hypoxic cells and reoxygenation in tumors

VIII Radiation Pathology
(a) Acute and late responding normal tissues
(b) General morphology of radiation injury
(c) Acute radiation syndromes
(d) Morphologic changes in irradiated tumors

IX Radiation Carcinogenesis
(a) Proto-oncogenes and tumor-suppressor genes
(b) Signal transduction and cell-cycle control
(c) Multi-stage carcinogenesis

Course Approval Form
Date: 7/9/04