ME 6794: Tissue
Engineering
| Credit
Hours: |
3-0-3 |
| Prerequisite: |
Consent
of instructor, graduate standing. |
| Catalog
Description: |
Biological,
engineering, and medical issues in developing tissue engineered constructs.
Emphasis is given on the integration of these disciplines at a basic molecular
and cell biology level. Crosslisted with BMED and CHE 6794. |
| Textbook: |
Notes
will be provided. |
Syllabus
Introduction
1. Historical
perspective of tissue engineering; industry and products
Cell Technology
- 2. Cells as
a core functional element of a bioartificial construct; required cell function
in constructs; sources of cells for tissue engineering applications
- 3. Influences
of cell function: culturing mode, chemical environment
- 4. Influences
of cell function: extracellular matrix, mechanical environment; structure/function
relationships
- 5. Cell procurement
of auto-, allo-, and xenogeneic cells; genetic engineering of cells for
tissue engineering applications; cell amplification in culture; stem cells
Biomaterials
Technology
- 6. Biomaterials
in tissue engineering: definitions; functional requirements of biomaterials
in tissue engineering applications
- 7. Polymeric
materials in tissue engineering; modifications for eliciting specific cellular/tissue
responses
- 8. Biomimetic
materials; biological substrates
Bioartificial
Construct Technology
- 9. Introduction;
design considerations; three-dimensional structure; multi-cellular systems
- 10. Diffusion-based
and vascularized constructs; transport of nutrients and metabolites
- 11. Immunoacceptance
of transplanted cells: immunocompatibility, immunomodulation, immunoisolation
- 12. Scale up
of manufacturing processes
- 13. Preservation
of tissue engineered constructs
- 14. Regulation
of tissue-engineered products by FDA
- 15. Methodology
of pre-clinical trials; safety, efficacy, clinical end-points
- 17. Integration
of constructs into living systems; interface/connection with surrounding
tissue; chronic adaptation/remodeling in vivo
Products in the
Early Stages of Development: Critical Issues Being Faced
- 18. Cartilage
tissue engineering
- 19. Bone tissue
engineering: materials, architecture, and mechanical properties; repair
and remodeling; cells and growth factors
- 20. Cardiovascular
substitutes
- 21. Neural tissue
engineering: synthetic guidance systems; neurotrophic molecules; functionalized
three-dimensional gels; schwann cell seeding
Products Now
Approaching the Market Place: Lessons for the Next Generation of Products
- 22. Skin substitutes
- 23. Encapsulated
cell therapies
Evaluation:There
is a midterm exam and a term project, involving both a written report and
an oral presentation.
Course
Approval Form