ME 6793 Systems Pathophysiology

ME 6793: Systems Pathophysiology
Offered Every Fall

Credit Hours:	3-0-3
Prerequisite:	Graduate standing in engineering or related discipline
Catalog Description:	Overview of human pathophysiology from a quantitative perspective. Emphasis on systems of interest to bioengineering faculty. A brief introduction to quantitative models for biological systems. Crosslisted with BMED, CHE, and ECE 6793.
Textbook:	Sue E. Huether and Kathryn L. McCance; Understanding Pathophysiology, 2nd Edition, Elsevier Science, 2003.
Instructors:	Robert Guldberg, David Ku, invited lecturers

Goals:

Prepare students for graduate education in bioengineering by providing them with the rudiments of human physiology and pathology. Also provide a brief introduction to the method by which engineering principles are applied to biological systems for the purposes of understanding and predicting pathophysiology.

Outline:

1. Cardiovascular System Pathophysiology

a. overall structure: Anatomy and Physiology; Microscopic anatomy of arteries and veins
b. pathology: Atherosclerosis; Congenital disease; Hypertension; Valvular disease; Intimal Hyperplasia; Thrombosis
c. treatment: Diagnostic Techniques; Therapy

2. Blood

a. components
b. what it's for: i. immunity; ii. nutrients; iii. waste removal; iv. tissue repair
c. pathology: leukemia; cycle cell anemia

3. Neural System

a. overall structure

b. electrically active cells

action potential

c. information processing

d. motor functions

e. CNS/PNS

f. autonomic/voluntary

i. sympathetic/parasympathetic

4. Bones, tendons, ligaments, and muscles

a. overall structure and physiology

b. muscle-bone interaction

c. pathology

osteoporosis

arthritis

5. Renal

a. components

b. what it's for

i. blood pressure

ii. waste excretion

c. pathology

obstructive uropathy

nephropathy

_______________________
Revised June 2004