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ME 6794: Tissue Engineering
| Credit Hours: |
3-0-3 |
| Prerequisites: |
Consent of instructor, graduate standing. |
| Catalog Description: |
Biological, engineering, and medical issues in developing tissue engineered constructs. Emphasis is given on the integration of these disciplines at a basic molecular and cell biology level. Crosslisted with BMED and CHE 6794. |
| Textbooks: |
Notes will be provided. |
| Topics: |
- Introduction
- Historical perspective of tissue engineering; industry and products
- Cell Technology
- Cells as a core functional element of a bioartificial construct; required cell function in constructs; sources of cells for tissue engineering applications
- Influences of cell function: culturing mode, chemical environment
- Influences of cell function: extracellular matrix, mechanical environment; structure/function relationships
- Cell procurement of auto-, allo-, and xenogeneic cells; genetic engineering of cells for tissue engineering applications; cell amplification in culture; stem cells
- Biomaterials Technology
- Biomaterials in tissue engineering: definitions; functional requirements of biomaterials in tissue engineering applications
- Polymeric materials in tissue engineering; modifications for eliciting specific cellular/tissue responses
- Biomimetic materials; biological substrates
- Bioartificial Construct Technology
- Introduction; design considerations; three-dimensional structure; multi-cellular systems
- Diffusion-based and vascularized constructs; transport of nutrients and metabolites
- Immunoacceptance of transplanted cells: immunocompatibility, immunomodulation, immunoisolation
- Scale up of manufacturing processes
- Preservation of tissue engineered constructs
- Regulation of tissue-engineered products by FDA
- Methodology of pre-clinical trials; safety, efficacy, clinical end-points
- Integration of constructs into living systems; interface/connection with surrounding tissue; chronic adaptation/remodeling in vivo
- Products in the Early Stages of Development: Critical Issues Being Faced
- Cartilage tissue engineering
- Bone tissue engineering: materials, architecture, and mechanical properties; repair and remodeling; cells and growth factors
- Cardiovascular substitutes
- Neural tissue engineering: synthetic guidance systems; neurotrophic molecules; functionalized three-dimensional gels; schwann cell seeding
- Products Now Approaching the Market Place: Lessons for the Next Generation of Products
- Skin substitutes
- Encapsulated cell therapies
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| Grading Scheme: |
Midterm Exam |
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Term Project (written and oral) |
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