Ph.D. Thesis Defense by Murat Khamzin
Friday, Octoberber 8, 2002

(Dr. John Valentine, advisor)

"Data Acquisition and Analysis for the Energy-Subtraction Compton Scatter Camera for Medical Imaging"

Abstract

In response to the shortcomings of the Anger camera currently being used in
conventional single photon emission computed tomography (SPECT),
particularly the trade-off between sensitivity and spatial resolution, a
novel energy-subtraction Compton scatter camera, or the ESCSC, has been
proposed. A successful clinical implementation of the ESCSC could
revolutionize the field of SPECT. Features of this camera include
utilization of silicon and CdZnTe detectors in primary and secondary
detector systems, list-mode time stamping data acquisition, modular
architecture, and post-acquisition data analysis. Previous ESCSC studies
were based on Monte Carlo modeling. The objective of this work is to test
the theoretical framework developed in previous studies by developing the
data acquisition and analysis techniques necessary to implement the ESCSC.
The camera model working in list-mode with time stamping was successfully
built and tested thus confirming potential of the ESCSC that was predicted
in previous simulation studies. The prototype was based on a two-detector
system (Si and CdZnTe). The obtained data were processed during the
post-acquisition data analysis based on preferred event selection criteria.
Along with the construction of a camera model and proving the approach, the
post-acquisition data analysis was further extended to include preferred
event weighting based on the likelihood of a preferred event to be a true
preferred event. While formulated to demonstrate ESCSC capabilities, the
results of this study are important for any Compton scatter camera
implementation as well as for coincidence data acquisition systems in
general.