Education

  • M.D., Emory University, 1984
  • Ph.D., Georgia Institute of Technology, 1983
  • M.S., Georgia Institute of Technology, 1982
  • B.A., Harvard University, 1978

Research Areas and Descriptors

Background

Dr. Ku was named to the Huang Chair in 2000. He began at Tech in 1986 as an Assistant Professor. Prior, he was the Fulbright Gastprofessor in Munich, Germany and a Fellow in Cardiovascular Pathology at the University of Chicago.

Research

Dr. Ku has an active interest in peripheral vascular pathology and unsteady, threedimensional fluid dynamics. One project investigates the relative role of hemodynamics and thrombosis in vascular graft occlusion. Additional studies involve the development of a tissue-engineered vascular graft. Noninvasive magnetic resonance imaging is used to determine the hemodynamics and detect pathology in vivo. Computational solutions explore fluid mechanic variations from geometry. Another project studies the collapsible tube behavior of highly stenotic arteries.

Dr. Ku has an active interest in cardiovascular pathophysiology, unsteady threedimensional fluid mechanics, medical implants, and commercialization of university research. Basic research focuses on sudden cardiac death from platelets subjected to high shear and plaque rupture due to arterial stenosis collapse. His research extends to Translational Technology using applied biomedical engineering to impact patient care and therapy. Projects span from device design to development of bench tests to predict clinical performance. Dr. Ku teaches entrepreneurship and product development to bring technological solutions to the bedside.

Dr. Ku's work is supported by the National Institutes of Health, the National Science Foundation, the American Heart Association, and the Whitaker Foundation. His collaborative work is performed with Emory University, Worcester Polytechnic Institute, and the Swiss Federal Institute of Technology in Lausanne, Switzerland.

Distinctions

  • American Society of Mechanical Engineers
    • Gustus L. Larson Memorial Award, 1996
    • Journal of Biomechanical Engineering Associate Editor, 1995-1998
    • Y. C. Fung Young Investigator Award (Bioengineering Division), 1989
  • Georgia Institute of Technology
    • Zeigler Outstanding Educator in the Woodruff School, 2009
    • Student Government Association Faculty Member of the Year, 1999
    • Outstanding Doctoral Thesis Advisor, 1995
    • Woodruff School Faculty Fellow, 1991-1996
  • Sigma Xi (Georgia Tech Chapter) Best Master’s Thesis Advisor Award (Laura Lee Farrell), 2008
  • \American Institute for Medical and Biological Engineering Fellow, 1998
  • Journal of Vascular Investigation Associate Editor, 1994-1999
  • American Heart Association Young Investigator Award, 1989
  • National Science Foundation Presidential Young Investigator Award, 1987-1992
  • Fulbright Fellowship (Germany), 1985
  • Licensed M.D. in Georgia and Illinois

Patents

  • System and Method for Analyzing a Medical Image, U. S. Patent 6,377,832, with Harris Bergman, April 23, 2002
  • Poly(vinyl alcohol) Cryogel, U. S. Patent No. 5,981,826, with L. G. Braddon and D. M. Wootton, November 9, 1999
  • Apparatus and Method for Treating Articles in Solution with Effervescent Tables, U. S. Patent No. 5,756,044, with M. Mowrey-McKee, and others, May 26, 1998.
  • Flow Induced Artifact Elimination in Magnetic Resonance Images, U. S. Patent No. 5,438,992, with J. Siegel, J. H. Oshinski, and R. I. Pettigrew, August 8, 1995
  • Flow Differentation Scheme for Magnetic Resonance Argiography, U. S. Patent No. 5,521,502, May 28, 1996

Representative Publications

  • E. M. Lutostansky, et al. 2003. Analysis of Hemodynamics Fluid Phase Mass Transport in a Separated Flow Region. Journal of Biomechanical Engineering 125, 189-196.
  • D. Tang, et al. 2002. Simulating Cyclic Artery Compression Using a 3D Unsteady Model with Fluid-Structure Interactions. Computers and Structures 80, 1651-1665.
  • H-C Han and D. N. Ku. 2001. Contractile Responses in Arteries to Hypertensive Pressure in 7-Day Organ Culture. Annals of Biomedical Engineering 29(6), 467-475.
  • D. Tang, et al. 2001. Steady Flow and Wall Compression in Stenotic Arteries: A Three- Dimensional Thick-Wall Model with Fluid-Wall Interactions. Journal of Biomechanical Engineering 123, 548-557.
  • D. M. Wootton, et al. 2001. A Mechanistic Model of Acute Platelet Accumulation in Thrombogenic Stenoses. Annals of Biomedical Engineering 29(4), 321-329.